The main thing to worry about is just the boss, as with willpower, you can heal continuously over the previous three fights (if you play close to the defender).
My main strategy is - patience. First several days had bosses that are difficult because of the time pressure of Degeneration coupled with power gain. G2099 can go invisible and mess up your attempts to reset the degen clock. Other bosses that can't be parry stunned in an on-demand manner (Emma Frost, Stealth), would make the fight too stressful.
As a side note: I tried a few runs using the Prestige < 10k method (using the AuntM.ai calculator) and it never seemed to trigger despite being under 10k. In the end, went with under 10K PI team.
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My main strategy is - patience. First several days had bosses that are difficult because of the time pressure of Degeneration coupled with power gain. G2099 can go invisible and mess up your attempts to reset the degen clock. Other bosses that can't be parry stunned in an on-demand manner (Emma Frost, Stealth), would make the fight too stressful.
As a side note: I tried a few runs using the Prestige < 10k method (using the AuntM.ai calculator) and it never seemed to trigger despite being under 10k. In the end, went with under 10K PI team.