I am going to assume you are asking this for a completion run, take 2 skill champs and 3 other class high dmg champs.Use Nick fury and Blade for tough/boss fights,doom,sunspot and hulkbuster for lane clearing ,mostly bait sp1s and you are good to go,fights may be long tho.
act 5.2.5 has bane node....use champs that stun...or champs that have big Sps animation(sunspot's sp 1).....use nick for high damage in 2nd life....havok ....power control champs...dr doom(sp 1 after sp3).......colossus(high damage).....save sp 3 of champs when you are caught by degen....VTD is a good option against armoured champs(like civil warrior in easiest path) torch can also be good option
Comments
Fury
Doom
Havok after rank 4
Hulkbuster
Void or quake after max