Really depends what your 5 and 6* rosters look like. If you really don't have any worthy 6*s for rank to like me, then I'd stick with 5* champs for the time being. But if you do then it's good to focus on them so that you can look towards rank 3 in the future.
Nick fury is currently your only rank 3 worthy 6* imo, so since you already have him as a five star I would for sure forcus on your 5* roster instead you got a lot of good options there (hyperion, warlock, aegon, medusa, ghost, human torch, corvus)
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