If you have a lot of champions, preferably 4*, you can grind the arena for the 4* shards in the rank rewards. When you form 4* crystals and open dupes from them, you will get 24x T5 class ISO, and that's a lot.
Of course, this is a pretty long process and you probably want some quick ISO. In that case, you can do 4.3.6 as what Kenshio has mentioned above, since you can easily get a lot of ISO for as little energy as possible. You can also use the units you grinded from the arena and invest them into energy refills so you can repeatedly grind 4.3.6.
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Of course, this is a pretty long process and you probably want some quick ISO. In that case, you can do 4.3.6 as what Kenshio has mentioned above, since you can easily get a lot of ISO for as little energy as possible. You can also use the units you grinded from the arena and invest them into energy refills so you can repeatedly grind 4.3.6.