As far as I know, Spider-Ham is the only champ that can go immune to degen. Gladiator Hulk can regenerate 75% of the damage on some nodes and a max sig namor can just reflect the damage back. Hope that helps.
No champion can nullify it (not a buff in the first place) and no champion is immune to it. Some champions are able to resist it, either go indestructible during the time being or reduce the potency of it
Comments
Some champions are able to resist it, either go indestructible during the time being or reduce the potency of it