Which 5* should I take to rank 4?

AlbinoDarkElf

About to get the last 2 Tier 2 Alphas I need. Here is a list of 5*s I have, who should I take to rank 4 or should I wait?

Captain Marvel (Movie)
Havok
Domino
Hulkbuster
Guillotine 2099
Hit-Monkey
Nova
Cable
Spider-Man (Classic)
Agent Venom

I just started playing around Thanksgiving and I'm having trouble progressing. I just recently got Uncollected. I tried to look at tier lists, but for example I have trouble ramping up Guillotine 2099 to 100+hits so she isnt as good for me and I just use her for alliance defense.

Yodabolt21

First off, don't do rank ups based on tier lists.... do it based on how you like the champ and your roster.

G2099, Domino, CMM or HB are your best bets. I know you say you can't ramp her up to 100+ hits, but if you finish a fight with the sp3, you start the next fight with a 100 combo.

I really would recommend her as she is double immune, regen and power control.