The only mastery that enhances a champions built in regen is the recovery mastery. Increases regeneration by 15% at 3/3.
For Omega Red, maxed Willpower plus 1 point in coagulate will make him 100% bleed resistant, letting you heal off any bleeds via will power. This is especially effective if running suicides, since the 1st 16 seconds of the fight is all regen.
Matthew950
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For Omega Red, maxed Willpower plus 1 point in coagulate will make him 100% bleed resistant, letting you heal off any bleeds via will power. This is especially effective if running suicides, since the 1st 16 seconds of the fight is all regen.