Mephisto regeneration on master quest

I just used all my revives up trying to defeat Master level mephisto. :-(
Even the soul blade couldn't block his regeneration ability.
I used my strongest heroes:
Guillotine 4*
Punisher 4*
X23 5* (unawake)
Gamora 4*
Drax 5* (unawake)

Please tell me how I can block his regeneration and defeat him???
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