i disliked that quest. nick fury twice, nova twice, domino twice. hyperion made it a lot easier, but i'm sure a lot of new cavs struggled on that one if they were trying to do exploration.
Try to keep all your champs alive till her. Then use 2 champs for her. You can take boss with other 2. And keep 1 for safety. I used 6* R2 venom, 5* r4 angela, 6* sas, 6* mags. Kept 5* Doom as backup. Used angela and venom for domino. Be prepared, you will get it done.
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I smashed it with my cmm 6*r3.