Suicides are mainly used to better arena points I would say the suicides are useful in story quests and event quests cos you get insane damage not good for AQ or AW
I like using suicides. I currently only have LC turned on and dropped DE and added Deep Wounds and Assassin instead. I have plenty of poison immune champs for any heal block nodes so AQ, AW attack and quests are not a problem. I do take a hit on AW defense but I like the extra attack and PI boost in arena. For me the positive is greater than the negatives. Also just Google MCOC mastery setup and you will find all sorts of good builds out there.
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