Out of the options listed, Domino for sure. But it really depends. A beefy Apocalypse is among the worst, in my opinion, simply because he's got so gosh-darn much health that you need to chip down. He's not particularly hard to fight in BG since he isn't fully ramped up, but he just takes so much time to kill.
Sauron is a pain as well due to his frequent unblockable attacks and his hard-to-dex SP1, although I've found more and more good counters for him (War Machine and Tigra, looking at you).
Storm PX is also annoying due to all of the glancing. It makes it hard to actually do anything and you just end up chipping away at her. Luckily she isn't as beefy as Apocalypse so that chipping doesn't take as much time as it does versus Big Daddy Apoc, but it's still really annoying without the right counter.
Yeah, that's the "asking for a friend" part of the poll...
I still have my 5* Mutant 4>5 rank up gem and want to use it on a mutant that I can bring for BG defense... Those in the poll are my 5* options... However, although I do have an awakening gem as well, I don't have a lot of sig stones...
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Sauron is a pain as well due to his frequent unblockable attacks and his hard-to-dex SP1, although I've found more and more good counters for him (War Machine and Tigra, looking at you).
Storm PX is also annoying due to all of the glancing. It makes it hard to actually do anything and you just end up chipping away at her. Luckily she isn't as beefy as Apocalypse so that chipping doesn't take as much time as it does versus Big Daddy Apoc, but it's still really annoying without the right counter.
I still have my 5* Mutant 4>5 rank up gem and want to use it on a mutant that I can bring for BG defense... Those in the poll are my 5* options... However, although I do have an awakening gem as well, I don't have a lot of sig stones...
I already have a 6* Apoc, and a 6* bishop...