Pretty much any poison immune champ that also deals damage over time like Hyperion for example. His L1 can be spammed to cut through the safeguard. IceMan's cold snap, Dormammu's heavy could do some direct damage and if Degen kicks in also would do well, Ultron with some bleeds would help, Nebula and shock, etc I'm sure I missed a few.
just take a poison immune champ and smack him around. hes not hard to fight just got to be patient. If you think he is rough just wait till you get to the stun immune venompool
Comments
It's been a long time, so I don't know if there's any other special nodes on that guy. I only know he has nodes that enhance his poison abilities.