You should mainly focus on 4* and up but if your stuck at a point in the game and your choices are like a 4* spidergwen or 3* Blade I'd go with the 3 since it would be more beneficial
I think it really depends where you are at in the game and what your goals are. For example, which arenas do you grind out the most? Also, are you looking to rank up 3*/4* to use for questing/aq/aw or are you looking to rank up to help your overall base hero total?
I pretty much have my aq/aw/quest teams figured out so I don't level up any 4* champs to 5/50 or 5* champs to 3/45 (or 4/55) unless they will be game changers for my account. Right now I am trying to slowly max out my 2* and 3* then will eventually r3 all my 4* and r2 all my 5* help out with my arena scores.
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The 3*s still help with Normal and Heroic monthly event quest when your best champs are tied up in AW and AQ
I pretty much have my aq/aw/quest teams figured out so I don't level up any 4* champs to 5/50 or 5* champs to 3/45 (or 4/55) unless they will be game changers for my account. Right now I am trying to slowly max out my 2* and 3* then will eventually r3 all my 4* and r2 all my 5* help out with my arena scores.