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Glass Cannon mastery?

Is it worth it? Was thinking about saving up for it but.not sure how much of a damage difference it makes
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But in all seriousness, I think it's fantastic - you'll notice the attack gain much more than the health loss, especially if you're in the mid-to-late game. What's your roster and the rest of your mastery tree like?
In general, I'd recommend it if you've got points to spend, and you've built out the essentials around Parry/Dex, Cruelty, Precision, Block Proficiency, etc.
I agree with dizzy that it isnt an essential mastery but defo worth considering.
Other options to consider are:
Mystic dispersion - aw def and power gen in questing
Deep wounds - bleed champs (blade heal)
Assassins - large boss fights, rol, lol.
As someone else mentioned take the points out of prefect block (its not worth it... the only reason to have 1 point there is if you want to get "Stand Your Ground" which is an "okay" mastery). Also your "Energy Resistance", Pierce, and Fury points are a waste as well. "Courage" is okay (I think most who have higher end expensive masteries run only one point).
After that if you have good heal champs like Ultron, Ghost Rider, Wolvie, X-23, ect then you might want to get the "Recovery" mastery. Also I persoanlly run both Petrify and Pacify in Utility.
Lastly you should get a few points in Mystic Dispersion (looks like you unlocked it so you have one slot at least already).
Hope this helps!
After that basically I would suggest Deep Wounds and Assassin later down the road if you can ever afford them (its like 6,000 units or something crazy to max one so I persoanlly am going to settle for Glass Cannon for a long while).
Here is a pic of my setup which should be easier then trying to figure out what is what in my reply earlier (again hope this helps and if you have any questions feel free to post here or PM me):