Hyperion, yondu, kingpin, morningstar, IW iron man, og spidey, green goblin, would be your best defenders. hood on an enhanced special 2 node, ultron on a regen node can be slightly effective. I personally don't think Sabertooth is a great defender, the regen isn't that terrible to deal with.
Comments
Spidey Classic is only amazing when duped and high sig level
They've got a 4* spidey that's duped, so that one would be placed in defense when ranked higher.