If your a new player, medusa is the way to go. She gains furies which increase attack, and if you get hit, they will be consumed to auto block which is useful if a combo fails. But the best use for medusa is on alliance war defense. However, for her to be good on defense, you need to unlock a mastery called parry. When people try fighting medusa, the auto block will activate and stun the opponents. She also has high health, and a Posion immunity. If you go with medusa, you shouldn't have too many problems clearing content. Hela is also pretty good, but doesn't need to be awakened.
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