The typical advice is to push as far as you can in the monthly EQ then move forward to permanent content during the last week and a half when you finish. That way you can maximize on rewards.
Depending on your roster I’d say after fully exploring act 4 , for those mastery points mainly, try to finish act 5. If you happen to have a Ghost or Sentinel you should consider variant 3.
I do have a maxed 4* ghost though I don't have any of her synergy partners ranked up, still thanks for the advice
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