How beneficial are the sigs for FAM?

Hearing different views on this with some saying sig 1 is all you need for the damage reduction but some saying sig 200 beneficial.
How noticable is the regen when facing him on defense at high sig? Feel like most bleeders/cosmics should be able to get around it either way with despair mastery
On attack it seems more niche, but maybe the regen can help against fights like Onslaught
How noticable is the regen when facing him on defense at high sig? Feel like most bleeders/cosmics should be able to get around it either way with despair mastery
On attack it seems more niche, but maybe the regen can help against fights like Onslaught
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Comments
But when the bleeds proc, more than the regen, the 90% reduction means a lot. It's a pseudo immunity.
Valkyrie is one of my choices to fight him because of her pierces. But once she starts doing those instant bleeds, he starts regenning and slows her down.
He can take bullseye because of that reason too