Void is the only behond god tier science, aweken or not.
Without his dupe he has a hard time reversing healing and powergain since all debuffs just fall off after the 6th one. Fear of the void is what really makes him good since it ups his damage to a good level and makes it easy to stack up petrify. If you don't run despair unduped he can't reverse healing or powergain at all and it takes him considerably longer to get his debuffs on at all.
Comments
Basically this.
R4 is fine unduped. If you're short DOT champs he's fine for 5/50
What team?
The Killmonger & Sabretooth snyergy. Sometimes called the "Unholy Trinity".
Without his dupe he has a hard time reversing healing and powergain since all debuffs just fall off after the 6th one. Fear of the void is what really makes him good since it ups his damage to a good level and makes it easy to stack up petrify. If you don't run despair unduped he can't reverse healing or powergain at all and it takes him considerably longer to get his debuffs on at all.