Domino is very good on her own. I play her to max combos and use either the special 3 bleed and refresh or spam l2. If you have redhulk synergy she is better for heavy attacks. I do prefer this synergy, so good against annoying champs like medussa and modok. Even unawakened and no synergies she would still be worth an r5. I rarely play massacre synergy with her but it is a very nice bonus.
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P.s.Worth maxing deep wounds for her.
If i hadnt have needed corvus glaive r5 for aq and aw, i would have totally taken her up.