Based on what I can infer from the node’s description, it only makes melee hits unblockable. However, in the video, it appears punisher’s sp2 bullets are unblockable. I show the nodes at the start of the video, I am in 5.1.3, and have the Dr Doom “I answer to no one” synergy active.
https://youtu.be/jmdH8e-0xeA