How hard is Variant 5 first clear. Can I do it?

My best roster atm for this variant is
5R5 Doon
5R4 Sym Supreme
5R3 Starky
4R5 Venom
4R5 Scarlet Witch
Would a first clear on easy paths be very costly (in terms of units, revives) with this team?
5R5 Doon
5R4 Sym Supreme
5R3 Starky
4R5 Venom
4R5 Scarlet Witch
Would a first clear on easy paths be very costly (in terms of units, revives) with this team?
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Comments
I didn’t have Sym Supreme in my team, but looking at the global buffs, it seems that this Variant was made for him.
I have a R4 Starkey that I used for fights Doom couldn’t do (Sentinel and his power steal resistance 🙄)
As for those 4 stars, you can use them, but they are gonna take a LOT of block damage. You would need to have near-perfect play with them. Try them out on the first chapter, and if you think the block damage if too much, take in some synergies. I rotated in Miles for a 7 hit combo with Starkey and Diablo for the heavy crits with Doom.
My team also included a 6 star R1 Ebony Maw and Longhot. Longshot was stupidly fun for the final Venom, absolutely cheesed him. In 1.2, there is a Breakthrough lane, and I used Maw for all of it except for Iceman. I used Doom because of his high health pool (R5) and realized after there is a Dr. Strange synergy that would purify the coldsnap when activating the Aura. I would have brought that if I had thought about it.
Overall a very fun Variant, but you need Doom (especially for the 3.1 boss). I hope you enjoy your run! I did mine itemless, btw.