Anyone whose first M attack has 2 strikes. Just completely screws up my timing and makes some really good champs like Domino or Stealthy completely unplayable for me.
Colossus, even thought his playtime is pretty simple in that it's just heavy spam,I really don't feel comfortable playing him. I have done great things with my hyperion,domino(with the trinity),beardo and archangel amongst others but I don't do very well with Colossus even though it's almost the exact same style. It just is that way for me.
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Also, "waiting game" champs like Void, or Omega Red. I just really suck at sitting through and waiting for their damage to pile up.