I used a 5/50 Ultron. My main thing was all the damn random effects from all the specials he threw. I waited until he got power lock on him and then just beat him down through the regen.
Aside from the obvious Guillotine/Quake options, I'd suggest you max out Despair mastery; then use your Gwenpool, Medusa or X-23 to stack lots of bleeds. These can suppress his healing and deal damage at the same time. If you can armour shatter then inflict lots of bleed, he won't heal at all.
Honestly, if you have willpower, most debuff that get put on you will just heal you if you play correctly. Just don’t get hit by his specials, keep armour break, power lock, regen, weakness or anything that doesn’t damage you but triggers will power, and just keep attacking him until he’s used up both regens
He has predictable and predetermined regen. Just think of him having 30k more health than he really does and keep hitting him. He is easy to bait and evade, and short of him getting unstoppable over and over, he will go down.
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No other champ comes close to the beat down he gives. Sp1 all day. Goldy down without regen... Plus bleed and weakness.
My 5/50 destroyed him everytime.
Even iceman got it done reasonably easy.