Already mentioned in the (excellent) list above by @RandomizerRuns_4 , but I will stress it again: Doctor Octopus. Especially an awakened one. Heal block & power lock as soon as the fight starts with a Heavy hit. Keep spaming those to keep it going and smash him.
I feel like scarlet witch is a possibility IF You have some serious rng luck. I did most of the path wayyyyy back with her and she couldn’t keep up with his heals.
It can be done with blade as well with l3 spam and max despair. Sym spidey is one not many think of you can parry and heavy his armour breaks last 90 seconds and stack. Cross Bones works well together never crits so Wolverine will never regen. It can also be done with rogue, domino, omega red, wasp, sentinel,
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Seriously, it's how the pros did it back in the day.
Under 50 seconds.
Didn’t mention all the common champs said